Description
| SKU # | E-AB-10483 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Applications | WB, IHC |
Product Details
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human NCK1 |
| Abbre | NCK1 |
| Synonyms | Cytoplasmic protein NCK1,MGC12668,Melanoma Nck protein,NCK,NCK 1,NCK adaptor protein 1,NCK alpha,NCK tyrosine kinase,NCK1,NCKalpha,Nck-1,Non catalytic region of tyrosine kinase,SH2/SH3 adaptor protein NCK alpha,SH2/SH3 adaptor protein NCK-alpha |
| Swissprot | P16333 |
| Calculated MW | 43 kDa |
| Cellular Localization | Cytoplasm. Endoplasmic reticulum. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments. |
| Concentration | 0.3 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer,Epigenetics and Nuclear Signaling,Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Related Reagents
| Applications | Recommended Dilution |
| WB | 1:200-1:1000 |
| IHC | 1:50-1:200 |
Background
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
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