Description
| SKU # | PKSH032725 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CRSBP-1,CRSBP1,Cell Surface Retention Sequence-Binding Protein 1,Extracellular Link Domain-Containing Protein 1,HAR,Hyaluronic Acid Receptor,LYVE-1,LYVE1,Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1,XLKD1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu20-Thr 238 |
| Accession | AAH26231.1 |
| Calculated Molecular Weight | 24.6 kDa |
| Observed Molecular Weight | 46 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per g of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80. Reconstituted protein solution can be stored at 4-8 for 2-7 days. Aliquots of reconstituted samples are stable at < -20 for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 m filtered solution of 20mM Tris-Citrate, 150mM NaCl, pH 7.0. Normally 5% – 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is a single-pass type I membrane protein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells 1. LYVE-1 mainly expressed in endothelial cells lining lymphatic vessels. While LYVE-1 functions is a Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. LYVE-1 plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). It may act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
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