Description
| SKU # | PKSH033517 |
| Expression Host | E.coli |
Description
| Synonyms | Mediator of IRF3 activation,Stimulator of interferon genes protein,TMEM173,sting |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Val155-Val341 |
| Accession | Q86WV6 |
| Calculated Molecular Weight | 33.8 kDa |
| Observed Molecular Weight | 35 kDa |
| Tag | N-SUMO-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per g of the protein as determined by the LAL method. |
| Storage | Store at < -20C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20C. |
| Formulation | Supplied as a 0.2 m filtered solution of 20mM HEPES, 100mM NaCl, 10% Glycerol, pH8.0. |
| Reconstitution | Not Applicable |
Background
Stimulator of Interferon Gene(Sting,TMEM173) belongs to the TMEM173 family. STING is 379 amino acids (aa) in length. It contains an N-terminal cytoplasmic region (aa 1-20), four transmembrane segments (aa 21-173), and a C-terminal cytoplasmic domain (aa 174-379). It ubiquitously expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophagesand. Its subunit structure associated with the MHC-II complex and Interacts with DDX58/RIG-I, MAVS and SSR2, RNF5 and TRIM56 along with TBK1. This type of protein often uses as facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon.
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