Tribioscience Sirtinol, SIRT Inhibitor

Tribioscience Sirtinol, SIRT Inhibitor

Buy Tribioscience products from MSE Supplies at the best value.

Product Details

Formal Name:2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide

Molecular Formula:C26H22N2O2

Formula Weight:394.50

CAS Number:410536-97-9

Purity:>98%

Formulation:powder

Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).

Storage:-20C / protect from light

Stability: 1 year.

Applications

SIRT inhibitor

Functions

Selective sirtuin inhibitor which does not effect HDAC1, IC50 = 131, 38 and 68 M for SIRT1, SIRT2 and Sir2P respectively. Induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Suppresses survivin expression which correlates with decreased viability in HT29 colon cancer cells. Displays pro-inflammatory effects in adipocytes. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20 for up to 1 month.